abstract：:Mammalian embryonic diapause is a phenomenon defined by the temporary arrest in blastocyst growth and metabolic activity within the uterus which synchronously becomes quiescent to blastocyst activation and implantation. This reproductive strategy temporally uncouples conception from parturition until environmental or ...

journal_title：Open biology

authors： Cha J,Sun X,Bartos A,Fenelon J,Lefèvre P,Daikoku T,Shaw G,Maxson R,Murphy BD,Renfree MB,Dey SK

更新日期：2013-04-24 00:00:00

abstract：:In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive extracellular stimuli through cell surface receptors, and transmit signals to ion channels, enzymes and other effector proteins to affect numerous cellular behaviours. In plants, G proteins have structural similarities to the correspondin...

journal_title：Open biology

authors： Urano D,Chen JG,Botella JR,Jones AM

更新日期：2013-03-27 00:00:00

abstract：:Vitamin B₁₂-dependent enzymes function in core biochemical pathways in Mycobacterium tuberculosis, an obligate pathogen whose metabolism in vivo is poorly understood. Although M. tuberculosis can access vitamin B₁₂ in vitro, it is uncertain whether the organism is able to scavenge B₁₂ during host infection. This quest...

journal_title：Open biology

authors： Gopinath K,Venclovas C,Ioerger TR,Sacchettini JC,McKinney JD,Mizrahi V,Warner DF

更新日期：2013-02-13 00:00:00

abstract：:Following thymic output, αβ⁺CD4⁺ T cells become activated in the periphery when they encounter peptide-major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages and subsequent expansion and contraction during an appropriate and...

journal_title：Open biology

authors： Coomes SM,Pelly VS,Wilson MS

更新日期：2013-01-23 00:00:00

abstract：:RANKL (receptor-activator of NF-κB ligand, TNFSF11) is a member of the TNF superfamily that regulates bone remodelling and the development of the thymus, lymph nodes and mammary glands. While RANKL and its membrane bound receptor RANK (TNFRSF11A) are expressed in the adult central nervous system and have been implicat...

journal_title：Open biology

authors： Gutierrez H,Kisiswa L,O'Keeffe GW,Smithen MJ,Wyatt S,Davies AM

更新日期：2013-01-08 00:00:00

abstract：:Heat shock protein 90 (Hsp90) is a promising cancer drug target as a molecular chaperone critical for stabilization and activation of several of the oncoproteins that drive cancer progression. Its actions depend upon its essential ATPase, an activity fortuitously inhibited with a very high degree of selectivity by nat...

journal_title：Open biology

authors： Piper PW,Millson SH

更新日期：2012-12-12 00:00:00

abstract：:Leucocytes form the principal cellular components of immunity and inflammation, existing as multiple subsets defined by distinct phenotypic and functional profiles. To date, this has most notably been documented for lymphocytes and monocytes. In contrast, as neutrophils are traditionally considered, to be short-lived,...

journal_title：Open biology

authors： Beyrau M,Bodkin JV,Nourshargh S

更新日期：2012-11-01 00:00:00

abstract：:Genetic material can be transmitted not only vertically from parent to offspring, but also laterally (horizontally) from one bacterial lineage to another. Lateral genetic transfer is non-uniform; biases in its nature or frequency construct communities of genetic exchange. These biases have been proposed to arise from ...

journal_title：Open biology

authors： Skippington E,Ragan MA

更新日期：2012-09-01 00:00:00

abstract：:Understanding gene regulation requires knowledge of changes in transcription factor (TF) activities. Simultaneous direct measurement of numerous TF activities is currently impossible. Nevertheless, statistical approaches to infer TF activities have yielded non-trivial and verifiable predictions for individual TFs. Her...

journal_title：Open biology

authors： Rolfe MD,Ocone A,Stapleton MR,Hall S,Trotter EW,Poole RK,Sanguinetti G,Green J,SysMO-SUMO Consortium.

更新日期：2012-07-01 00:00:00

abstract：:The presence of foetal DNA in the plasma of pregnant women has opened up new possibilities for non-invasive prenatal diagnosis. The use of circulating foetal DNA for the non-invasive prenatal detection of foetal chromosomal aneuploidies is challenging as foetal DNA represents a minor fraction of maternal plasma DNA. I...

journal_title：Open biology

authors： Lo YM

更新日期：2012-06-01 00:00:00

abstract：:Innate immunity relies entirely upon germ-line encoded receptors, signalling components and effector molecules for the recognition and elimination of invading pathogens. The fruit fly Drosophila melanogaster with its powerful collection of genetic and genomic tools has been the model of choice to develop ideas about i...

journal_title：Open biology

authors： Kounatidis I,Ligoxygakis P

更新日期：2012-05-01 00:00:00

abstract：:The innate immune response is the first line of defence against infection. Germ-line-encoded receptors recognize conserved molecular motifs from both exogenous and endogenous sources. Receptor activation results in the initiation of a pro-inflammatory immune response that enables the resolution of infection. Understan...

journal_title：Open biology

authors： Bryant CE,Monie TP

更新日期：2012-04-01 00:00:00

abstract：:We here address the question of whether there is any correlation between subjective preference for simple configurations within a specific visual domain such as motion and strength of activity in visual areas in which that domain is emphasized. We prepared several distinctive patterns of dots in motion with various ch...

journal_title：Open biology

authors： Zeki S,Stutters J

更新日期：2012-02-01 00:00:00

abstract：:Redox conditions change in events such as immune and platelet activation, and during viral infection, but the biochemical consequences are not well characterized. There is evidence that some disulfide bonds in membrane proteins are labile while others that are probably structurally important are not exposed at the pro...

journal_title：Open biology

authors： Metcalfe C,Cresswell P,Ciaccia L,Thomas B,Barclay AN

更新日期：2011-11-01 00:00:00